mancozeb 80% WP blue powder China manufacturer

mancozeb 80% WP blue powder China manufacturer

mancozeb 80% WP blue powder,25KG/BAG 1KG/500G/250G/100G/ALU BAG

NOMENCLATURE

Common name mancozeb (BSI, E-ISO); mancoze ((m) F-ISO); manzeb (JMAF)

IUPAC name manganese ethylenebis(dithiocarbamate) (polymeric) complex with zinc salt  

Chemical Abstracts name [[1,2-ethanediylbis[carbamodithioato]](2-)]manganese mixture with [[1,2-ethanediylbis[carbamodithioato]](2-)]zinc  

CAS RN [8018-01-7] (formerly [8065-67-6]); number also applies to other mixed manganese and zinc ethylenebis(dithiocarbamate) complexes  

PHYSICAL CHEMISTRY

Composition The ISO definition is 'a complex of zinc and maneb containing 20% of manganese and 2.55% of zinc, the salt present being stated (for instance mancozeb chloride)'. A manufacturer gives the ratio of maneb to zinc as 1:0.091, i.e. 20% Mn and 2.2% Zn.  Mol. wt. 271.2 (based on Composition)  M.f. [C4H6MnN2S4]xZny  Form Greyish-yellow, free flowing powder with a slight odour of hydrogen sulfide.  M.p. Decomposes at 172    V.p. <1.33 ?10-2 mPa (20  )  KOW logP = 0.26  S.g./density 1.92  Solubility In water 6.2 ppm (pH 7.5, 25  ). Insoluble in most organic solvents; dissolves in solutions of powerful chelating agents but cannot be recovered from them.  Stability Stable under normal, dry storage conditions. Slowly decomposed by heat and moisture. On hydrolysis (25  ), DT50 20 d (pH 5), 17 h (pH 7), 34 h (pH 9). Mancozeb a.i. is unstable and the tech. not isolated; the formulated product is produced in continuous process.  F.p. 137.8   (Tag open cup)  

COMMERCIALISATION

History Fungicide reported in Fungic. Nematic. Tests, 1961, 17.Introduced by Rohm & Haas Co. (now Dow AgroSciences) and by E. I. du Pont de Nemours and Co. (who no longer manufacture or market it).  Patents GB 996264; US 3379610; US 2974156 all to Rohm & Haas  Manufacturers Agrochem; Aimco; CAC; Cerexagri; Crystal; Dow AgroSciences; Griffin; Hindustan; Indofil; United Phosphorus

APPLICATIONS

Biochemistry Reacts with, and inactivates the sulfhydryl groups of amino acids and enzymes of fungal cells, resulting in disruption of lipid metabolism, respiration and production of ATP.  Mode of action Fungicide with protective action.  Uses Control of many fungal diseases in a wide range of field crops, fruit, nuts, vegetables, ornamentals, etc. More frequent uses include control of early and late blights (Phytophthora infestans and Alternaria solani) of potatoes and tomatoes; downy mildew (Plasmopara viticola) and black rot (Guignardia bidwellii) of vines; downy mildew (Pseudoperonospora cubensis) of cucurbits; scab (Venturia inaequalis) of apple; sigatoka (Mycosphaerella spp.) of banana and melanose (Diaporthe citri) of citrus. Typical application rates are 1500-2000 g/ha. Used for foliar application or as a seed treatment. Formulation types DP; DS; OD; SC; WG; WP.  Selected products: 'Dithane M-45' (Dow AgroSciences); 'Dithane' (Dow AgroSciences); 'Fore' (Dow AgroSciences); 'Manconex' (Griffin); 'Manex II' (Griffin); 'Manzate' (Griffin); 'Sancozeb' (Dow AgroSciences); 'Aimcozeb' (Aimco); 'Caiman' (Calliope); 'Crittox' (Siapa); 'Defend M 45' (Crop Health); 'Devidayal M-45' (Devidayal); 'Hilthane' (Hindustan); 'Indofil M-45' (Indofil); 'Ivory' (Calliope); 'Kifung' (Inquiport); 'Lucazeb' (Lucava); 'Mancosol' (Ingenier Industrial); 'Mancothane' (Vapco); 'Manzeb' (Barclay); 'Micene' (Sipcam); 'Policar MZ' (Cequisa); 'Saver' (Sanonda); 'Uthane' (United Phosphorus); 'Vimancoz' (Vipesco); 'Zeb' (Nagarjuna Agrichem); mixtures: 'Electis' (+ zoxamide) (Dow AgroSciences); 'Equation Contact' (+ famoxadone) (DuPont); 'Gavel' (+ zoxamide) (Dow AgroSciences); 'Manex C-8' (+ cymoxanil) (Griffin); 'Sygan PM' (+ cymoxanil+ folpet) (Griffin); 'Syphal PM' (+ copper oxychloride+ cymoxanil+ folpet) (Griffin); 'Curtine-V' (+ cymoxanil) (Vapco); 'Duett' (+ cymoxanil) (Cequisa); 'Hawaii' (+ metalaxyl) (Rocca); 'Micexanil' (+ cymoxanil) (Sipcam); 'Mike' (+ flumorph) (Shenyang); 'Milor' (+ metalaxyl) (Rotam); 'Pulsan' (+ oxadixyl+ cymoxanil) (Syngenta); 'Roxam' (+ zoxamide) (Interfarm); 'Sandofan' (+ oxadixyl) (Syngenta); 'Tairel' (+ benalaxyl) (Sipcam); 'Talman-combi' (+ metalaxyl) (Cequisa); 'Trecatol' (+ benalaxyl) (Isagro)

ANALYSIS

Product analysis CIPAC Handbook, 1998, H,195; in mixture with copper compounds by iodometric titration of liberated carbon disulfide (ibid., 1998, H, 96); determination of manganese by titration, (ibid., 1994, F, 232); ETU content by hplc or paper chromatography (ibid., 1994, F, 399). Residues determined by reaction with acid to form carbon disulfide which is measured by standard methods (Analyst (London), 1981, 106, 782; Pestic. Anal. Man., 1979, II; Manu. Pestic. Residue Anal., 1987, I, S21; Anal. Methods Residues Pestic., 1988, Part II).  

MAMMALIAN TOXICOLOGY

Reviews FAO/WHO 68, 70 (see part 2 of the Bibliography).  Oral Acute oral LD50 for rats >5000 mg/kg.  Skin and eye Acute percutaneous LD50 for rats >10 000, rabbits >5000 mg/kg. No irritation to skin (rabbits); moderate eye irritant (rabbit, EU standards), not an eye irritant (rabbit, U.S. standards) No dermal sensitisation in Buehler test; may cause dermal sensitisation in guinea pig maximisation test.  Inhalation LC50 (4 h) for rats >5.14 mg/l.  NOEL NOEL for rats 4.0 mg/kg b.w. daily. NOAEL for ethylenethiourea 0.37 mg/kg b.w. daily. Below toxic levels, mancozeb was observed to have no effect on reproduction, on neonatal survival, or on growth.  ADI (JMPR) 0.03 mg/kg b.w. (group ADI with maneb, metiram and zineb); ethylenethiourea 0.004 mg/kg b.w. [1993]; mancozeb 0.05 mg/kg b.w.  Other At very high, maternally toxic levels, mancozeb has caused birth defects in test animals; ethylenethiourea, a trace contaminant and breakdown product of mancozeb, has caused thyroid effects, tumours and birth defects in laboratory animals.  Toxicity class WHO (a.i.) U; EPA (formulation) IV  EC classification Xi; R37| R43  

ECOTOXICOLOGY

Birds Acute oral LD50 (10 d) for mallard ducks >5500, Japanese quail 5500, English sparrow (Passer domesticus) >1290, European starling (Sturnus vulgaris) >2400 mg/kg. Acute dietary LC50 (8 d) for bobwhite quail and mallard ducks >5200 mg/kg diet. Chronic reproduction NOEL for mallard ducks 125, bobwhite quail 300 mg/kg diet.  Fish LC50 (96 h, flow-through) for rainbow trout 1.0, bluegill sunfish >3.6 mg/l; (96 hr static-renewal) for rainbow trout 0.15, 0.088, 0.074, bluegill sunfish 0.083, common carp (Cyprinus carpio) 4.0, 3.3 mg/l; (96 h, static sediment/water microcosm) for rainbow trout 0.073, fathead minnow 0.57, bluegill sunfish 0.84, three-spined stickleback (Gasterosteus aculeatus) 0.93, Zebra fish 0.95, largemouth bass (Micropterus salmoides) 1.0, guppy (Poecilia reticulata) 1.3, Medaka (Oryzias latipes) 1.4, common carp 1.7 mg/l. NOEC (34 d, early life stage) for fathead minnow 0.022 mg/l; extended growth NOEC (14 d) for rainbow trout 0.66 mg/l.  Daphnia EC50 (48 h, flow-through) 3.8 mg/l; (48 h static-renewal) 0.073 mg/l; (24 h, static) 0.011 mg/l; (48 h, static) 0.39 mg/l.  Algae EC50 (120 h, cell density) for Selenastrum capricornutum 0.044 mg/l.  Other aquatic spp. EC50 (24 h) for rotifer (Brachionus calyciflorus) 0.11 mg/l; LC50 (48 h) for snail (Lymnae stagnalis) >113, for amphipod (Gammarus sp.) 3.0, for isopod (Asellus sp.) 4.4 mg/l. Outdoor mesocosm (macroinvertebrates and phytoplankton communities), 11 week, after 8 applications, Ecologically Acceptable Concentration 0.032 mg/l.  Bees LD50 (oral) >209 mg/bee; (contact) >400 mg/bee.  Worms LC50 (14 d) for Eisenia foetida >1000 mg/kg soil; 56 d reproduction NOEC for Eisenia foetida 20 mg/kg soil.  

ENVIRONMENTAL FATE

EHC 78 (WHO, 1988; general review of dithiocarbamates).  Mancozeb breaks down rapidly in soil, sediment and water; terminal metabolites are natural products and with mineralisation to carbon dioxide. It does not bioaccumulate.  Animals Poorly absorbed and rapidly excreted in animals. The spectrum of metabolites produced was similar in laboratory and farm animals, pointing to two common metabolic pathways, which both lead ultimately to the formation of glycine and to incorporation of the metabolites into natural products.  Plants Extensively metabolised in plants, forming ethylenethiourea, ethylenethiuram monosulfide, ethylenethiuram disulfide, and sulfur as transitory intermediates. Terminal metabolites are natural products, especially those derived from glycine.  Soil/Environment Rapidly degraded in the environment by hydrolysis, oxidation, photolysis, and metabolism. Soil DT50 <1 d (ave., 20  ). Koc 1000 ml/g.